Its position on the plain makes a walk through its historic center particularly pleasant. Among Foligno's main attractions are the Cathedral, its numerous oratories like the Nunziatella, that boasts a valuable fresco painted by the great Perugino, and the church of St. Maria Infraportas. Its absolute highlight is Palazzo Trinci, one of the few noble residences in central Italy. It proudly houses well-preserved original paintings from the early 1400's, some attributed to Gentile da Fabriano. In 1967 its Gothic staircase was the venue for a memorable show of international contemporary art, "The space of the Image", attracting famous artists like Fontana and Pistoletto.

The first edition of the Divine Comedy was printed in the Palazzo Orfini-Numeister printing house. Foligno can also be modern and contemporary. In fact it is the seat of the Italian Center for Contemporary Art  where you can admire one of the most important works of the 20th century Italian sculpture , the giant Cosmic Magnet of De Dominicis.